You could but you'd have to do a fair bit of presets to accomodate all the tunes you expect to play. Or you have some kind of pedal board that can control GR. Imagine in the middle of a gig and you have to tweak something. You run back to the computer, grab the mouse or use the trackpad and make changes, all the time hoping you don't drop your pick on the floor. Of course an interface that lets you dial in low buffer values. And a decent playback system that doesn't limit frequency response aka a full range flat response (FRFR) system.